--- title: "VKB V2 Filters: Account-Level vs. Case-Level Logic" description: Learn how to use the Spring 2026 VKB filter update. This guide explains the difference between the VKB and Current Analysis filter menus and how to combine them using AND/OR logic for precise variant discovery. --- [Skip to content](https://support.seqone.com/knowledge-base/vkb-v2-filters#main-content) [Contact us](https://support.seqone.com/knowledge-base/kb-tickets/new?hsLang=en) [Follow my tickets](https://support.seqone.com/tickets-view?hsLang=en) [![](https://support.seqone.com/hs-fs/hubfs/logo%20seqone-1.png?width=200&height=150&name=logo%20seqone-1.png)](https://support.seqone.com/knowledge-base?hsLang=en) - [Knowledge Base](https://support.seqone.com/knowledge-base) Open main navigation Close main navigation - [Knowledge Base](https://support.seqone.com/knowledge-base) - [Contact us](https://support.seqone.com/knowledge-base/kb-tickets/new) - [Follow my tickets](https://support.seqone.com/tickets-view) How can we help you? - There are no suggestions because the search field is empty. 1. [SeqOne KB](https://support.seqone.com/knowledge-base?hsLang=en) 2. [Analysis & Interpretation](https://support.seqone.com/knowledge-base/analysis-interpretation?hsLang=en) 3. [Workflows and Setup](https://support.seqone.com/knowledge-base/analysis-interpretation?hsLang=en#workflows-and-setup) October 9, 2026 # VKB V2 Filters: Account-Level vs. Case-Level Logic ## A guide to using the new two-layer filtering system to isolate consolidated VKB findings and sample-specific annotations. ### The New Two-Layer Filter System Following the **Spring 2026 Release**, the Variant Knowledge Base (VKB) has moved to a dual-layer architecture. To support this, the filter panel now features two distinct "Classification" menus. ![](https://support.seqone.com/hubfs/CleanShot%202026-05-07%20at%2012-05-31-png.png) - **"VKB" Filter:** Use this to filter based on **Consolidated Account-level** annotations (findings shared across your entire organization). - **"Current Analysis" Filter:** Use this to focus on the **Case-level** evaluations made specifically for the sample you are currently reviewing (including variants already added to your "Selection"). > 💡 **Tip:** You can combine both filters to find variants that have a specific global history *and* a specific status in your current case. --- ### Filter Logic The power of the V2 filters lies in how they handle multiple criteria. The system uses a specific combination of **OR** and **AND** logic. #### 1. Internal Logic: The "OR" Rule ![Example of Current Analysis filter](https://support.seqone.com/hubfs/CleanShot%202026-05-07%20at%2011-55-16-png.png) Within a **single** filter menu, the logic is **OR**. If you select multiple classifications or tags within one menu, the system will show variants that match *any* of those criteria. > **Example:** Selecting "Pathogenic," "Likely Pathogenic," and the "Hot VUS" tag in one menu will return variants that are Pathogenic **OR** Likely Pathogenic **OR** tagged as a "Hot VUS." #### 2. Between-Filter Logic: The "AND" Rule ![](https://support.seqone.com/hubfs/CleanShot%202026-05-07%20at%2011-53-44-png.png) When you use **both** the VKB and the Current Analysis filters together, the logic between them is **AND**. The variant must meet the requirements of both sets to appear in your results. - **Filter A (VKB**, figure on the left**):** Global status is Pathogenic OR Likely Pathogenic, OR Tag is "Tier 1", OR Tag is "Tier 2". - **Filter B (Current Analysis**, figure above**):** Sample status is Pathogenic OR Likely Pathogenic OR includes the "Hot VUS" tag. **The Result:** You will only see variants where **Filter A AND Filter B** are true: P+LP+hot vus variants reported in your analysis AND classified as P or LP or Tier 1 or Tier 2 in your VKB. - [Analysis & Interpretation](https://support.seqone.com/knowledge-base/analysis-interpretation?hsLang=en#main-content) - [Workflows and Setup](https://support.seqone.com/knowledge-base/analysis-interpretation?hsLang=en#workflows-and-setup) - [Technical Information](https://support.seqone.com/knowledge-base/technical-information?hsLang=en#main-content) - [Databases](https://support.seqone.com/knowledge-base/technical-information?hsLang=en#databases) - [AI Systems Documentation](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#main-content) - [UP2](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#up2) - [DiagAI LitFinder](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#diagai-litfinder) - [DiagAI Score](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#diagai-score) - [DiagAI HPO](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#diagai-hpo) - [DiagAI Autofill](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#diagai-autofill) - [PhenoGenius](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#phenogenius) - [UPP-SV](https://support.seqone.com/knowledge-base/ai-systems-documentation?hsLang=en#upp-sv) [![Chill listening crop-3](https://support.seqone.com/hs-fs/hubfs/logo%20footer.png?width=126&height=31&name=logo%20footer.png "Chill listening crop-3")](https://seqone.com) [mailto:support@seqone.com](mailto:support@seqone.com) Copyright © 2025, SeqOne